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Dietary, non-microbial intervention to prevent Helicobacter pylori-associated gastric diseases.
Han, Young-Min; Park, Jong-Min; Jeong, Migyeong; Yoo, Jun-Hwan; Kim, Won-Hee; Shin, Seok-Pyo; Ko, Weon-Jin; Hahm, Ki-Baik.
Affiliation
  • Han YM; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Park JM; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Jeong M; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Yoo JH; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Kim WH; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Shin SP; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Ko WJ; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
  • Hahm KB; 1 CHA University Cancer Prevention Research Center, CHA Bio Complex, Seongnam 463-400, Korea ; 2 Department of Gastroenterology, CHA University Bundang Medical Center, Seongnam 463-712, Korea.
Ann Transl Med ; 3(9): 122, 2015 Jun.
Article in En | MEDLINE | ID: mdl-26207250
Since the discovery of Helicobacter pylori (H. pylori) infection as the major cause of gastroduodenal disorders including acute and chronic gastritis, gastroduodenal ulcer, chronic atrophic gastritis, and gastric cancer almost three decades ago, the possibility of preventing these clinical diseases through eradicating H. pylori has been the focus of active research, but soon debate in the scientific community, though eradication opens the feasibility of cancer prevention and the removal of bacteria significantly prevents development or recurrence of peptic ulcer diseases and some clinical diseases, was proposed due to uncertainty in either achievement of complete eradication or inefficacy in cancer prevention with eradication alone. Still its linkage to gastric cancer is incontestable. Since the multiple combination of bacterial factors, environmental insults, and the host immune response that drives the initiation and progression of mucosal atrophy, metaplasia, and dysplasia toward gastric cancer is intervened, simple eradication deemed the feasibility of cancer prevention. Therefore, our group open strong hypothesis that non-microbial, dietary approach might be the alternate, for which several interventions of nutritional components can highlight rejuvenation of chronic atrophic gastritis as well as amelioration of H. pylori-associated procarcinogenic inflammation. In this review article, the experience and outcome regarding nutritional application to rejuvenate gastric atrophy will be introduced, using Korean red ginseng, garlic extracts, cancer preventive Korea kimchi, n-3 polyunsaturated fatty acids (PUFA), special form of licorice, and probiotics. The detailed influence of dietary intervention and bacterial eradication therapy on disease progression and reversibility of premalignant lesions are discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: Ann Transl Med Year: 2015 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: Ann Transl Med Year: 2015 Document type: Article Country of publication: